Detection of AmpC β Lactamases producing Enterobacteriaceae
.bmp)
Overview AmpC β Lactamases is one of the clinically important causes of drug-resistant in Enterobacteriaceae. the first isolates producing acquired AmpC were identified at end of 1980, and since then they have been observed globally. Detection of organisms producing this enzyme can be difficult, there is no standard guideline available at present. these enzyme detection and characterization are important in epidemiological and clinical. Three different phenotypic tests to detect AmpC β Lactamases producing organisms. Definition AmpC-type cephalosporins are ambler class C β -Lactamases. they hydrolyze penicillins, monobactams, and cephalosporins including the third-generation but not the fourth-generation compounds. In general, AmpC- type enzyme are poorly inhibited by classical ESBL inhibitors, especially clavulanic acid. Clinical importance of AmpC detection The major producer species of acquired AmpCs are E.coli, K. pneumoniae, K. oxytoca, Salmonella enterica, and P...